ELC20-NCE16: What Do We Know About Living Cells?

Speakers

Program Track: Tissue Engineering and Hard Tissue Reconstruction

Does the advent of living cells enhance regeneration? Various approaches have been introduced to enhance clinical outcomes of ridge augmentation and periodontal regeneration. In the last decade, additional sources of graft materials from autogenous and allogeneic sources have become available to deliver live cells to the graft site. For alveolar ridge augmentation, allograft cells derived from amniotic tissue has been applied in combination with cadaver bone for alveolar ridge augmentation. Researchers have also conducted the “Cell Sheet Engineering Technology”, temperature-responsive cell culture of periodontal ligament derived mesenchymal stem cells (PDL-MSCs), in the treatment of severe periodontal defects. This session will review:

1. In alveolar ridge augmentation, how these cells are harvested and used in the different graft materials. Also, the advantages and disadvantages of using live cells will be discussed and clinical cases using different cellular graft approaches will be shown.
2. In periodontal regeneration, clinical cases will be presented using the PDL-MSC sheets with beta-tricalcium phosphate, and the mode of action of the material will be speculated. The potential of allogeneic PDL-MSC will also be discussed.

Educational Objectives:

• Consider cell viability in the different graft preparations and cell survivability once grafted.
• Determine what studies should be performed to validate cellular graft strategies.
• Recognize clinical cases where the use of cellular grafts has given excellent clinical outcomes.
• Show the translational research and clinical cases of periodontal ligament derived mesenchymal stem cells (PDL-MSC) sheets.
• Speculate the mode of action of cell therapy.
• Discuss the potential of allogeneic PDL-MSC sheets.